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Best automatic washing machines in March 2025: Top 10 picks for performance and efficiency

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Best automatic washing machines in March 2025: Top 10 picks for performance and efficiency


An automatic washing machine makes life easier for homemakers, whether you are a housewife or a working woman. It saves time and effort by handling laundry with just a few button presses. No need to spend hours scrubbing clothes—modern machines clean efficiently while you focus on other tasks.

Effortless washing with smart technology—automatic machines for quick, efficient, and hassle-free laundry care.

For busy women, it’s a lifesaver, allowing more time for family or work. Features like quick wash, different fabric settings, and energy-saving modes make washing simple and convenient. With advanced technology, these machines remove tough stains while being gentle on fabrics. An automatic washing machine is a must-have for every home, making laundry stress-free and manageable.

We have put together a list of 10 of the best options in fully automatic washing machines. Check them out.

The LG 7 Kg 5 Star Smart Inverter Technology Fully Automatic Top Load Washing Machine (T70VBMB1Z) offers a blend of efficiency and convenience. Its Smart Inverter Technology optimises energy consumption, resulting in quieter and more durable operation. The TurboDrum™ feature ensures a thorough wash by creating a powerful water flow that moves the drum and pulsator in opposite directions, effectively removing tough stains. Additionally, the Smart Diagnosis™ feature allows for quick troubleshooting via a smartphone app, enhancing user convenience. While the machine boasts advanced features, it does not include Bluetooth connectivity.

What buyers are saying on Amazon?

Customers appreciate the machine’s quiet operation and effective cleaning performance. Some users note the absence of a soak option and express concerns about the build quality.

Why choose this product?

Choose this washing machine for its energy efficiency, effective cleaning, and user-friendly features. However, note the lack of advanced connectivity options.

The Whirlpool 7 Kg 5 Star Royal Fully-Automatic Top Loading Washing Machine (WHITEMAGIC ROYAL 7.0 GENX) offers several features designed to enhance washing efficiency. Its Hard Water Wash function adapts the wash cycle for hard water conditions, ensuring better detergent action and fabric care. The Zero Pressure Fill (ZPF) technology allows the wash tub to fill 50% faster, even when water pressure is low, reducing waiting times. Additionally, the machine’s 1-2-3 Wash System simplifies operation with a user-friendly three-button control panel. However, this model does not include Bluetooth connectivity.

What buyers are saying on Amazon?

Customers appreciate the machine’s effective cleaning and ease of use. Some users express concerns about noise levels and build quality.

Why choose this product?

Choose this washing machine for its adaptability to hard water, efficient performance, and user-friendly design. Note the absence of advanced connectivity options.

The Whirlpool 7 kg Magic Clean 5 Star Fully Automatic Top Load Washing Machine (MAGIC CLEAN 7.0 GENX GREY 5YMW) offers several features designed to enhance washing efficiency. Its Hard Water Wash programme ensures effective cleaning even in hard water conditions, adapting the wash cycle to maintain detergent efficacy and fabric care. The Zero Pressure Fill (ZPF) technology enables the tub to fill quickly even when water pressure is low, reducing waiting times. Additionally, the Magic Lint Filter automatically collects and cleans lint during the spin cycle, minimising manual intervention. However, this model does not include Bluetooth connectivity.

What buyers are saying on Amazon?

Customers appreciate the machine’s effective cleaning and user-friendly features. Some users mention concerns about noise levels and the absence of an in-built heater.

Why choose this product?

Choose this washing machine for its adaptability to hard water, efficient performance, and user-friendly design, ensuring thorough cleaning.

The Whirlpool 7.5 Kg 5 Star StainWash Royal Plus Fully Automatic Top Load Washing Machine (SW ROYAL PLUS 7.5 (H) GREY 10YMW) offers advanced features for superior laundry care. Its in-built heater provides three hot water modes, ensuring thorough cleaning and effective stain removal. The Stainwash programme is designed to tackle up to 50 tough stains, even those up to 48 hours old. Additionally, the 6th Sense Technology automatically senses and adjusts wash parameters for optimal performance. However, this model does not include Bluetooth connectivity.

What buyers are saying on Amazon?

Customers appreciate the machine’s effective stain removal and energy efficiency. Some users note the absence of advanced connectivity features and prefer a front-load design.

Why choose this product?

Choose this washing machine for its superior stain removal capabilities and energy efficiency, ensuring clean and fresh laundry.

The Samsung 7 kg Fully-Automatic Top Load Washing Machine (WA70A4002GS/TL) offers efficient and reliable laundry solutions. Its Centre Jet Technology generates powerful water currents, ensuring thorough cleaning by lifting clothes during washing. The Diamond Drum design provides a gentle wash, reducing fabric wear and tear. Additionally, the Eco Tub Clean feature keeps the drum hygienic without harsh chemicals. However, this model does not include Bluetooth connectivity.

What buyers are saying on Amazon?

Customers appreciate the machine’s effective cleaning and user-friendly operation. Some note the limited wash programmes and absence of advanced features.

Why choose this product?

Choose this washing machine for its efficient cleaning, gentle fabric care, and reliable performance, suitable for small families.

The Samsung 7 kg Fully-Automatic Top Load Washing Machine (WA70BG4441YYTL, Lavender Gray) offers advanced features for efficient laundry care. Its Eco Bubble Technology ensures effective cleaning even at low temperatures by generating bubbles that help detergent penetrate fabric quickly. The Digital Inverter Motor provides energy-efficient and quiet operation, enhancing durability. Additionally, the soft-closing door prevents abrupt closures, ensuring safety and convenience. However, this model does not include Bluetooth connectivity.

What buyers are saying on Amazon?

Customers appreciate the machine’s quiet operation and effective cleaning. Some note limited wash programmes and lack of advanced features.

Why choose this product?

Choose this washing machine for its energy efficiency, quiet operation, and effective cleaning performance, ensuring reliable laundry care.

The Panasonic 6 Kg 4 Star Fully-Automatic Top Load Washing Machine (NA-F60LF1HRB, Grey) offers efficient and convenient laundry solutions. Its Aquabeat Wash Technology ensures thorough cleaning by generating powerful water flows that effectively remove dirt from fabrics. The One Touch Smart Wash feature simplifies operation by automatically selecting the optimal wash programme based on load and fabric type. Additionally, its durable metal body enhances longevity. However, this model does not include Bluetooth connectivity.

What buyers are saying on Amazon?

Customers appreciate the machine’s effective cleaning and user-friendly features. Some users note the absence of advanced connectivity options.

Why choose this product?

Choose this washing machine for its efficient cleaning, durable build, and user-friendly features, ensuring reliable laundry care.

The LG 8 Kg 5 Star Fully-Automatic Front Load Washing Machine (FHB1208Z4M, Middle Black) offers advanced features for efficient laundry care. Its AI Direct Drive™ technology detects fabric softness and selects optimal motions, ensuring gentle yet thorough cleaning. The Steam™ feature eliminates 99.9% of allergens, providing hygienic washes. With LG ThinQ® technology, you can control and monitor your washing machine remotely via Wi-Fi, enhancing convenience. Additionally, the 6 Motion Direct Drive technology moves the drum in multiple directions, giving fabrics proper care while getting clothes ultra-clean.

What buyers are saying on Amazon?

Customers appreciate the machine’s efficient cleaning, quiet operation, and smart features. Some note the higher price point but find the quality justifies the cost.

Why choose this product?

Choose this washing machine for its intelligent fabric care, energy efficiency, and convenient smart features, ensuring superior laundry results.

The LG 9 Kg 5 Star Fully-Automatic Front Load Washing Machine (FHP1209Z5M, Middle Black) offers advanced features for superior laundry care. Its AI Direct Drive™ technology detects fabric softness and selects optimal washing motions, ensuring gentle yet thorough cleaning. The Steam™ feature eliminates 99.9% of allergens, providing hygienic washes. With Wi-Fi connectivity through LG ThinQ®, you can control and monitor your washing machine remotely, enhancing convenience. Additionally, the 6 Motion Direct Drive technology moves the drum in multiple directions, giving fabrics proper care while getting clothes ultra-clean.

What buyers are saying on Amazon?

Customers appreciate the machine’s efficient cleaning, quiet operation, and smart features. Some note the higher price point but find the quality justifies the cost.

Why choose this product?

Choose this washing machine for its intelligent fabric care, energy efficiency, and convenient smart features, ensuring superior laundry results.

The LG 8 Kg 5 Star Smart Inverter Technology Fully Automatic Top Load Washing Machine (T80VBMB4Z, Middle Black) is designed to enhance your laundry experience. Its Smart Inverter Technology ensures energy-efficient and quiet operation by adjusting the power consumption based on load size. The TurboDrum™ feature provides a powerful wash by rotating the drum and pulsator in opposite directions, ensuring thorough cleaning. Additionally, the Auto Pre-Wash function tackles tough stains with a simple touch. While this model does not have Bluetooth connectivity, it includes Smart Diagnosis™, allowing you to troubleshoot issues via a smartphone app.

What buyers are saying on Amazon?

Customers commend its efficient washing performance and quiet operation. Some desire additional features like an in-built heater.

Why choose this product?

Opt for this washing machine for its energy efficiency, durable build, and effective stain removal capabilities.

Is an automatic washing machine good?

Yes, an automatic washing machine is highly convenient. It saves time, reduces effort, and ensures efficient cleaning. Ideal for busy households, it offers multiple wash cycles for different fabrics.

What is the difference between an automatic and normal washing machine?

An automatic washing machine handles washing, rinsing, and spinning with minimal effort, while a normal (semi-automatic) machine requires manual intervention to transfer clothes between wash and spin cycles.

Can we use a fully automatic washing machine without tap water?

Yes, but it requires manual water filling. Without a direct tap connection, you must pour water into the drum as needed, which reduces convenience and affects automatic functionality.

Top 3 features of best automatic washing machines

Best Automatic Washing Machine Brand Cycle Options
LG 7 Kg 5 Star Smart Inverter Technology Fully Automatic Top Load (T70VBMB1Z) LG Multiple wash programs

Auto Prewash, Smart Diagnosis

Whirlpool 7 Kg 5 Star Royal Fully-Automatic Top Load (WHITEMAGIC ROYAL 7.0 GENX) Whirlpool Hard Water Wash, ZPF Tech Detergent Dispenser
Whirlpool 7 kg Magic Clean 5 Star Fully Automatic Top Load (MAGIC CLEAN 7.0 GENX GREY 5YMW) Whirlpool Magic Clean, 12 Wash Programs Auto Tub Clean
Whirlpool 7.5 Kg 5 Star StainWash Royal Plus Fully Automatic Top Load (SW ROYAL PLUS 7.5) Whirlpool StainWash, In-Built Heater

Automatic Detergent Dispenser

Samsung 7 kg Fully-Automatic Top Load (WA70A4002GS/TL) Samsung Normal, Quick, Delicate Magic Dispenser
Samsung 7 kg Eco Bubble Tech Fully-Automatic Top Load (WA70BG4441YYTL) Samsung Eco Bubble, Digital Inverter Magic Dispenser
Panasonic 6 Kg 4 Star Fully-Automatic Top Load (NA-F60LF1HRB) Panasonic 8 Wash Programs, AquaBeat
LG 8 Kg 5 Star Wi-Fi Direct Drive Fully-Automatic Front Load (FHB1208Z4M) LG Steam Wash, 6 Motion DD In-Built Heater
LG 9 Kg 5 Star AI Direct Drive Fully-Automatic Front Load (FHP1209Z5M) LG AI DD, Allergy Care Auto Dosing
LG 8 Kg 5 Star Smart Inverter Technology Fully Automatic Top Load (T80VBMB4Z) LG TurboDrum, Smart Inverter

Auto Prewash, Smart Diagnosis

Factors to keep in mind while choosing the best automatic washing machine

Capacity: Choose a washing machine based on your household size. A 6–7 kg model suits small families, while 8 kg or more is ideal for larger households.

Wash Programmes: Look for machines offering multiple wash cycles like quick wash, heavy load, and delicate fabrics for better convenience.

Energy Efficiency: Opt for a 5-star rated machine to save electricity and reduce water consumption over time.

Special Features: Smart features like Wi-Fi connectivity, inverter motors, and steam wash enhance performance and convenience.

Build Quality: A stainless steel drum ensures durability and better cleaning compared to plastic alternatives.

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FAQs on automatic washing machine

  • What is an automatic washing machine?

    An automatic washing machine handles washing, rinsing, and spinning without manual intervention, offering convenience and efficiency.

  • Do automatic washing machines require a continuous water supply?

    Yes, most need a steady water supply, but some allow manual water filling if necessary.

  • Which detergent is best for automatic washing machines?

    Use low-sudsing, high-efficiency detergents to prevent excess foam and ensure effective cleaning.

  • Can an automatic washing machine wash heavy items like blankets?

    Yes, but ensure the machine’s capacity suits heavy loads and use the appropriate wash cycle.

  • How long does an automatic washing machine last?

    With proper maintenance, it typically lasts 8–12 years.

Disclaimer: At Hindustan Times, we help you stay up-to-date with the latest trends and products. Hindustan Times has an affiliate partnership, so we may get a part of the revenue when you make a purchase. We shall not be liable for any claim under applicable laws, including but not limited to the Consumer Protection Act, 2019, with respect to the products. The products listed in this article are in no particular order of priority.



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WhatsApp’s new ‘Advanced Chat Privacy’ explained: Why is it important?

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WhatsApp’s new ‘Advanced Chat Privacy’ explained: Why is it important?


WhatsApp, in a bid to boost privacy for users, is has launched a new feature called Advanced Chat Privacy. This feature works in both group and personal chats, and allows users to have extra peace of mind, considering how it prevents content from being taken outside of WhatsApp. WhatsApp says the feature can actively block others from exporting chats, and this is where the real benefit lies.

WhatsApp says that Advanced Chat Privacy feature is currently rolling out.(WhatsApp)

Also Read: Gmail scam: Google says users have 7 days to recover hacked accounts

WhatsApp Advanced Chat Privacy Feature Explained

This feature is designed for times when you want more privacy, such as during a sensitive conversation with someone you’ve just started talking to, or someone who has yet to earn your trust.

“When the setting is on, you can block others from exporting chats, auto-downloading media to their phone, and using messages for AI features,” WhatsApp said in its blog post.

Not being able to take chats outside the chat is certianly going to make many feel secure, especailly more so considering media won’t be auto-downloaded, too.

If you’re wondering about the use cases, WhatsApp says it could be useful in situations such as discussing health challenges in a support group or organising your community around something important to you.

That said, there are a few drawbacks, including the fact that users can still take screenshots of chats, but WhatsApp notes that it is working on adding further protections soon.

Also Read: Instagram Blend explained: How to use this new feature

How To Start Using It

To start using Advanced Chat Privacy in WhatsApp, go to a chat and tap on Advanced Chat Privacy. This will enable the feature for you.

It should be noted that this is part of the latest WhatsApp app update, and WhatsApp has confirmed that it is indeed rolling out for everyone.

Mobile Finder: iPhone 16 LATEST Price, Specs And More



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A shade of OLO, e-waste wisdom, and Airtel’s silent recalibration

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A shade of OLO, e-waste wisdom, and Airtel’s silent recalibration


Let us begin our conversation with week with something thought-provoking (and also not as intense as AI, new smartphones and broadband bills; more on that later). Scientists, from the University of California Berkeley, University of Washington School of Medicine, and Herbert Wertheim School of Optometry & Vision Science claim to have discovered a new colour – OLO. A sophisticated technique involving lasers to stimulate specific cells in the human retina led to them seeing something that’s, simply put, a highly saturated blue-green hue. One could of course argue whether this is a new colour or not (that’s a nuanced argument, for anyone willing). Your world will unlikely change much with the discovery of a colour that cannot be seen without laser stimulation, but there’s a bigger question that may be at play here — can this become a step towards understanding colour blindness, and indeed solving unfortunate vision shortcomings, often because of macular degeneration?

OLO

RULES OF ENGAGEMENT

OpenAI
OpenAI

I always thought politeness was a basic tenet. Thank you. Please. Sorry (this word comes hardest to folks). But in the world of AI, apparently saying these words to an AI model, costs money. In response to someone musing how much politeness in general would have cost OpenAI in terms of electricity bills, CEO Sam Altman’s tongue-in-cheek reply still does enough to put things in perspective. “Tens of millions of dollars well spent–you never know,” he wrote.

But it takes me back to what Kurtis Beavers, a director on the design team for Microsoft Copilot, once said. “Using polite language sets a tone for the response,” he says. LLMs, or large language models (the very basis for generative AI) are trained on human conversations and use the tonality as a cue. Has your messenger or email app ever prompted you with the next word suggestion? That also takes cues from your tone and sentence structure till then. LLMs pick make similar assumptions and picks based on your input. When it notices politeness, it’s more likely to be polite in return.

This is a conflicting time for my daughter and myself, but unlikely we’ll change — we take pride in being polite with AI (and humans, let there be little doubt). We’ll not take a risk. What if one day, the machines do take over?

WASTE VS. WISDOM

For years, we were told by tech companies that the traditional hard disk drive (HDDs) were slow and therefore obsolete. The SSDs, or solid-state drives are the future (and have been, for almost a decade now) because they’re faster, more power efficient and have a much smaller footprint. Turns out, the physical footprint is in stark contrast to the environmental one. Seagate Technologies, one of the storage tech giants, in their latest ‘The Decarbonizing Data Report’ seems to be suggesting that we should return to using HDDs more than SSDs.

  • SSDs have the highest embodied carbon (rated at 4,915 Kg CO2), both in total and per TB, making it the most carbon-intensive option, with the HDD registering just 29.7 Kg CO2. “Hard drives exhibit the least carbon footprint, both in total and on a per-TB basis, offering the most carbon-efficient sustainable storage solution,” says the report. That is, less than 1 Embodied Carbon per TB, compared to 160 for an equivalent SSD.
  • This takes me to the thought of millions of Windows 10 PCs that will likely become obsolete later this year. Microsoft ends support for Windows 10 operating system in the middle of October, post which, many PCs that are incompatible with a Windows 11 upgrade, will end up in landfills. Most of these would be enterprise systems, and equally, quite a few personal systems too. Many of these will have SSDs. That is a significant volume of e-waste that we are potentially generating within a few months. Are we at all prepared?

WHAT’S ON MY MIND?

Sim Cards
Sim Cards

At some point in the past few days, Airtel and Blinkit had announced that the former would leverage the latter’s quick-commerce platform to deliver SIM cards to buyers, in that ballpark guarantee of 10-minute deliveries. Why I mention this now is, just yesterday, happened to order a few groceries from Blinkit (delivered within 12 minutes, with some ‘surge’ pricing, of course) — but an interesting thing was part of the package. In the carry bag, an interesting add-on. A SIM ejector pin, with unmissable Airtel and Blinkit branding. Suddenly you start contemplating your postpaid and prepaid subscription costs, a cursory glance at Airtel’s website to see the tariff plans (the Airtel Black plans make a lot of sense for most families), and before you know it, a new connection or a port request is in consideration. That is the power of smart branding, and quick-commerce.

These SIM cards, being delivered using Blinkit’s infrastructure, reduces investments and expenditure for Airtel’s own SIM delivery network. These SIMs can be set up as a new prepaid account, new postpaid account, or as a port-in from another network. With an online portal for KYC, or know-your-customer requirements, this also means you’d not have to visit a nearby Airtel store for the same (lesser traction at an Airtel store doesn’t harm the brand).

If you have used Reliance Jio’s iActivate service (as I have), you’ll realise Airtel’s process here doesn’t yet support eSIMs — the key here is, a physical SIM delivered by Blinkit → set up with KYC and choosing prepaid, postpaid or port-in → once active, use Airtel Thanks app to convert connection to eSIM. In Jio’s case, you can start with an eSIM from the off, and the QR is delivered to the registered email address, within a few minutes (or hours, depending on your luck that day) or hours following the KYC completion.

Should Vi or Jio also join the party?

RECALIBRATION

Airtel
Airtel

It has been many, many years since India’s broadband space saw tariff wars. We may be in for one. Or this could simply be a worrying sign, that your broadband bills are about to get a little more expensive. I raise the alarm because I’ve regularly checked broadband tariffs, expecting changes at some point (it has been a long wait, admittedly). Is Airtel is getting rid of 200Mbps Xstream Fiber plans?

  • Two parts to this story. The standalone Xstream Fiber plans now list four 100Mbps subscription options — 799 for just broadband and 999 (that is broadband + OTT streaming bundle including Netflix, Amazon Prime and JioHotstar). The erstwhile offering at 999 used to be a standalone 200Mbps Xstream Fiber plan, which seems to no longer be around.
  • The Airtel Black plans in many circles (I checked multiple, including Delhi, Mumbai and Hyderabad), which now pegs a 100Mbps plan at 899 (that is broadband + digital TV channels worth 350 + OTT streaming bundle) and another at 1199 (100Mbps broadband + digital TV channels worth 350 + OTT streaming bundle including Netflix and Amazon Prime). From the listed Black plans as well, any 200Mbps option is now missing.

For many homes, 100Mbps may be a tad on the lower side in terms of required speeds, considering we have so many phones, tablets, computing devices and smart TVs all scrambling for the same bandwidth. At the same time, a 300Mbps Xstream Fiber broadband line as part of the Airtel Black plan (there seems to be no standalone listed at this time) for 1,599 per month, may be an overkill. In my book, 200Mbps was the perfect balance for most home usage scenarios.

Off late, Reliance Jio Fiber has also eliminated its 150Mbps plans, and have a similar structure of 100Mbps and 300Mbps plans. While Jio Fiber also has 500Mbps as an option, Airtel’s Xstream offerings don’t have that balance between 300Mbps and 1Gbps. If at all that is an option (availability is often a question), Tata Play Broadband and ACT broadband may just provide that flexibility that Airtel Xstream doesn’t anymore.

There could still be some realignment in the coming days, but it seems in an urge to bundle OTT streaming subscriptions and digital TV (it could be a choice between DTH and IPTV), Airtel has taken away a crucial part of their Xstream Fiber subscriptions. Simplicity of plans.

Our detailed analysis of India’s broadband space…



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Not just DNA, proteins: CCMB team finds lipids also guide evolution

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Not just DNA, proteins: CCMB team finds lipids also guide evolution


Our bodies are made of cells. Each cell is a soup of smaller components, all working together to execute the body’s various functions. Perhaps the most well-known of these components are proteins — long chains of amino acids that cells make with instructions from the DNA. When the DNA changes, the cell is able to make new proteins, sometimes with new functions, and in this way proteins are understood to be an integral part of evolution.

But new research is finding that this may also be a narrow view that misses other ways in which we evolve.

“Lipids make up to 30% [of the dry weight] of living cells. But people think of them only as shells,” Sven Gould, an evolutionary cell biologist at the Institute for Molecular Evolution in Düsseldorf, said.

Time for an updated view

Lipids are fat in cells. A textbook image of the cell membrane (which is what Gould meant by “shell”) shows proteins jostling in a bed of lipids. Scientists know a lot about these membrane proteins. About 25% of all human proteins are estimated to be located in the membranes. They carry out many functions: as receptors, they bind to specific molecules outside the cell; as channels, they allow specific molecules to enter and leave the cell; and as catalysts, they help speed up chemical reactions.

On the other hand, scientists’ understanding of lipids is limited to their role as a packing material, as things that hold proteins. In fact, they’re often imagined to be arranged in a homogenous layer made of round heads and long, flowy tails — readymade for proteins to just be dropped on.

A study published recently in Nature Communications from Swasti Raychaudhuri’s lab at the CSIR-Centre for Cellular and Molecular Biology, Hyderabad, challenges this view.

The RC1 complex

The team’s study focused on a group of membrane proteins called respiratory complex 1 (RC1). RC1 and other similar complexes are essential for cells to produce energy when the body breathes oxygen. They are found in the mitochondrial inner membranes of all eukaryotic cells that require oxygen to respire — including ours.

RC1 is the largest of these respiratory complexes. In humans, it is an obtuse-angled complex made of 44 proteins in humans. Some of the proteins are made in the cell’s cytoplasm and some inside the mitochondria. They find their way to the mitochondrial inner membrane to form the complex.

To study RC1, the scientists divided it into three parts: one that faces the inside of the mitochondria and catalyses reactions for energy production during respiration; one that moves through the lipid-rich mitochondrial inner membrane and acts as a canal for hydrogen ions; and one that extends into the space between the inner and outer mitochondrial membranes and whose exact roles are not yet understood.

Since RC1 is essential for respiration in living cells, mutations in it are expected to cause diseases. When looking for known RC1 mutations associated with diseases, the research team found something unexpected in the inter-membrane RC1 part: half of the mutations were in regions that interact with lipids in the mitochondrial membranes.

Proteins and lipids together

Upon investigating further, the researchers found that the inter-membrane parts of RC1 as well as lipids in the membranes are not the same in all life forms. Plants and animals have different versions. Using precise biochemical techniques, the researchers examined the lipid variety in cells and found that plant lipids have a kinkier structure than their animal counterparts. They attributed this to plant lipids being rich in polyunsaturated fatty acids.

Using computational models, the team then compared the affinities between inter-membrane proteins of human and plant RC1s and a human and plant lipid called cardiolipin. It is the most prominent lipid found in the mitochondrial membranes.

They found that the proteins in human cells preferred human lipids over plant lipids, and vice versa. Similarly, in cultured cells, when team members inserted a part of plant RC1 that faces the lipids in the membranes into human mitochondrial membranes, they found that the complex disintegrated. In other words, the RC1 complex needs cardiolipin from organisms of the same kingdom for it to maintain its physical integrity. The team concluded that certain details in the structures and composition of lipids decide which proteins can exist with them.

Going a step further, the researchers have suggested that membrane lipids have evolved over time to suit the survival needs of different organisms. The kinkier tails of plant lipids offer greater structural flexibility in the membranes. This could have been because plant-like organisms have faced variegated environmental stresses through history, like drought, heat, and salinity, and benefit from having structurally flexible lipids.

Importantly, the proteins would then have had to co-evolve with the lipids to function correctly.

Need for new tools

In fact the new study may be the first to support the idea of lipid-protein co-evolution in mitochondrial membranes. Of course, it also holds up previous research that has demonstrated how lipids and proteins cross-talk in other membranes inside cells.

“Most labs study the roles of DNA, RNA, and proteins in evolution because a large community has grown around it,” Gould said. “However, evolution happens through all kinds of molecules that make up living cells and we need to study them.”

Not just in evolution: the study also opens up the possibility of understanding human health better. Drugs like statins are commonly used to control cholesterol — another prominent lipid — in cells. As scientists develop a fuller understanding of the roles lipids essay, they may assess and optimise the long-term use of substances like statins. The role of lipids in controlling the entry of pathogens into cells also demands attention.

However, these studies also require more sophisticated biological tools that don’t yet exist. Lipids are more complex molecules than proteins. While proteins are well-understood polymers consisting of 20 amino acids arranged in different ways, lipids are made of fatty acids that vary in length and chemical composition both. Their composition in particular is only partly controlled by an individual’s genes; the rest is influenced by diet and other environmental factors. Existing tools to study lipids also fall short when accounting for these complexities.

“It is extremely difficult to reconstitute lipids in labs. And membrane proteins are the toughest. But computational methods have developed faster than the biochemical tools,” Gould added. “Will these inspire more scientists to take up lipid biochemistry? That remains to be seen.”

It’s nevertheless clear that textbook images and the scientific imagination both need to change their attitudes towards membrane lipids. LDL, HDL, triglycerides, and cholesterol are already part of our daily consciousness. Studying these and other lipids further can thus help improve medical care as well as enhance our view of evolution. It’s a win-win.

Somdatta Karak, PhD heads science communication and public outreach at the CSIR-Centre for Cellular and Molecular Biology, Hyderabad.



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