On February 14, Pope Francis, 88, was hospitalised with a respiratory infection that developed into double pneumonia. Last weekend, when his condition deteriorated, doctors had warned that sepsis could become a major threat to his health. However, currently, doctors have said his condition is improving, though the prognosis continues to remain guarded.
What is sepsis?
Sepsis is a life-threatening medical emergency that takes place when your body has an extreme reaction to an infection. This reaction can lead to the damage of vital organs and cause death. In common parlance, it is sometimes known as blood poisoning.
In general, your immune system fights an infection that you have contracted. But in some cases, it stops fighting the infection and triggers widespread inflammation in your body, as well as blood clots. When this happens, blood flood to essential organs in your body is impaired, depriving them of nutrients and oxygen, and causing damage.
What are the common infections that can lead to sepsis?
Sepsis usually occurs due to bacterial infections, but can also result from other infections, including those of viruses, fungi, or parasites. There are some common types of and sites of infection that can lead to sepsis. These include: infections of the lung such as pneumonia or Covid-19; infections of the urinary tract system, such as bladder or kidney infections; infections of the skin, such as cellulitis; and infections of the gastrointestinal system, including those of the gallbladder, liver, and bowel.
Sepsis is not a contagious condition. However, the infection that caused it, may be.
Who is at risk of sepsis?
According to the World Health Organization (WHO), anyone affected by an infection, severe injury, or serious non-communicable disease can progress to sepsis, but vulnerable populations are at higher risk including: older adults, pregnant or recently pregnant women, neonates, hospitalised patients, and those with weakened immune systems and chronic medical conditions.
The WHO states that sepsis acquired in healthcare settings is one of the most frequent adverse events during care delivery and affects hundreds of millions of patients worldwide every year: for every 1,000 hospitalised patients, an estimated 15 patients will develop sepsis as a complication of receiving health care.
What are the signs and symptoms of sepsis?
There are several symptoms of sepsis. These include: feeling very cold, chills, and fever; rapid heart rate or low blood pressure; shortness of breath; warm or clammy skin; confusion or delirium; and severe pain or discomfort.
In children, the WHO says, symptoms can include: fast breathing, convulsions, pale skin, lethargy, difficulty waking up, and feeling cold to the touch. In children under five years, it can cause difficulty feeding, frequent vomiting, or lack of urination.
For people who have recently been in hospital, catheter sites and surgical wounds could become sites of infection.
Sepsis can progress very quickly. It is important to seek medical help as soon as possible for a diagnosis and treatment.
What is the treatment for sepsis?
The faster the treatment for sepsis is started, the more effective it is. Treatment generally includes antibiotics, and may include other medication such as vasopressers (to tighten blood vessels and help increase blood pressure), IV fluids to maintain blood flow to the organs, oxygen, if required, or other supportive care.
Preventing an infection is the best way to help prevent sepsis. Maintaining good hygiene including hand hygiene, keeping cuts and wounds clean and covered, keeping your immune system strong with a well-balanced diet and management of chronic conditions, and getting vaccinated on time are some ways that can help prevent infections.
Published – February 28, 2025 05:30 pm IST