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Study highlights lack of access to right antibiotics in eight countries

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Study highlights lack of access to right antibiotics in eight countries


Research carried out by Global Antibiotic Research and Development Partnership, a non-profit health organisation, has revealed that a significant number of multidrug-resistant infections in low- and middle-income countries, including India, are not being treated appropriately, because of large gaps in access.
| Photo Credit: Reuters

Only 7.8% of patients with drug-resistant infections in India received an appropriate antibiotic, a study of eight nations published in The Lancet Infectious Diseases journal has revealed. Lack of access to appropriate treatment for such serious infections increases morbidity and mortality, besides driving up health care costs and prolonging hospitalisation.

Research carried out by Global Antibiotic Research and Development Partnership (GARDP), a non-profit health organisation, has revealed that a significant number of multidrug-resistant infections in low- and middle-income countries (LMICs), including India, are not being treated appropriately, because of large gaps in access.

The study looked at which antibiotics were available to treat nearly 1.5 million cases of carbapenem-resistant Gram-negative (CRGN) infections across eight geographically diverse and populous LMICs — Bangladesh, Brazil, Egypt, India, Kenya, Mexico, Pakistan and South Africa. India’s 7.8% measures are against an average of 6.9% across all eight countries.

The study was undertaken to establish the barriers along the treatment pathway from initial presentation at the health facility to laboratory diagnostic testing to antibiotic access.

Two key parameters

The researchers defined and estimated two key parameters — the need for treatment or total number of resistant bacterial infections; the number of individuals potentially initiated on appropriate treatment, specifically focusing on CRGN infections. Researchers used The Lancet’s “Global Burden of Antimicrobial Resistance” (GRAM) study and IQVIA data for 2019 to arrive at the numbers.

“We were looking at three aspects,” explains Jennifer Cohn, GARDP’s Global Access Director and senior author of the study. “These were: To evaluate the access to antibiotics gap; create better data that will be an imperative to better define the cascade of care; and look at strong programmes or innovations that enabled better antibiotics stewardship in nations.” While the study only focused on eight countries, including India, she said there was a good reason to believe that the findings from this study also apply to other LMICs.

“We all know that high-end antibiotics are extensively overused and misused in countries like India, contributing significantly to resistance against these life-saving drugs. But this paper reminds us of an equally alarming issue — lack of access to these same antibiotics,” says Abdul Ghafur, infectious diseases specialist and founder, AMR Declaration Trust.

“In 2019, India had nearly 10 lakh carbapenem-resistant gram-negative infections, yet less than 1 lakh patients received appropriate treatment. The modelling suggests that around 3.5 lakh deaths occurred due to these infections. So we are caught in a paradox — irrational overuse on one end, and insufficient access on the other,” he added.

“To address this dual crisis, we must act on both fronts: preserve existing antibiotics through responsible use and ensure access to those who genuinely need them,” Dr. Ghafur further suggested. In the paper, authored by Anant Mishra et al, the recommendations are to set in place regulatory guardrails that will not only control antibiotics use, but also make sure that the access gap is bridged by nations and institutions. They also call for more research to better understand the barriers in accessing care, diagnoses and appropriate treatment.



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The US has nearly 900 measles cases, and 10 states have active outbreaks. Here’s what to know

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The US has nearly 900 measles cases, and 10 states have active outbreaks. Here’s what to know


With one-fifth of states seeing active measles outbreaks, the U.S. is nearing 900 cases, according to figures posted Friday by the U.S. Centers for Disease Control and Prevention (CDC).

US sees surge in measles cases

The CDC’s confirmed measles case count is 884, triple the amount seen in all of 2024. The now three-month-long outbreak in Texas accounts for the vast majority of cases, with 663 confirmed as of Tuesday. The outbreak has also spread to New Mexico, Oklahoma and Kansas.

Two unvaccinated elementary school-aged children died from measles-related illnesses in the epicenter in West Texas, and an adult in New Mexico who was not vaccinated died of a measles-related illness. Other states with active outbreaks — defined as three or more cases — include Indiana, Michigan, Montana, Ohio, Pennsylvania and Tennessee.

North America has two other ongoing outbreaks. One in Ontario, Canada, has resulted in 1,020 cases from mid-October through April 23. And as of Wednesday, the Mexican state of Chihuahua had 786 measles cases and one death, according to data from the state health ministry. Health officials in Mexico and the U.S. say all three outbreaks are of the same measles strain.

Measles is caused by a highly contagious virus that’s airborne and spreads easily when an infected person breathes, sneezes or coughs. It is preventable through vaccines, and has been considered eliminated from the U.S. since 2000. As the virus takes hold in other U.S. communities with low vaccination rates, health experts fear the virus that the spread could stretch on for a year. Here’s what else you need to know about measles in the U.S.

Outbreaks reported in multiple states

Texas state health officials said Tuesday there were 17 new cases of measles since Friday, bringing the total to 663 across 26 counties — most of them in West Texas. The state also added 23 hospitalisations to its count Tuesday saying they were from earlier in the outbreak, for a total of 87 hospitalisations. State health officials estimated about 1% of cases — fewer than 10 — are actively infectious.

Sixty percent of Texas’ cases are in Gaines County, population 22,892, where the virus started spreading in a close-knit, undervaccinated Mennonite community. The county has had 396 cases since late January — just over 1.5% of the county’s residents.

The April 3 death in Texas was an 8-year-old child, according to Health Secretary Robert F. Kennedy Jr. Local health officials in Texas said the child did not have underlying health conditions and died of “what the child’s doctor described as measles pulmonary failure.” An unvaccinated child with no underlying conditions died of measles in Texas in late February — Kennedy said age 6.

New Mexico remained steady Tuesday at 66 cases. Seven people have been hospitalised since the outbreak started. Most of the state’s cases are in Lea County. Three are in Eddy County and Chaves and Doña Ana counties have one each. State health officials say the cases are linked to Texas’ outbreak based on genetic testing. New Mexico reported a measles-related death in an adult on March 6.

Indiana confirmed two more cases April 21 in an outbreak that has sickened eight in Allen County in the northeast part of the state — five are unvaccinated minors and three are adults whose vaccination status is unknown. The cases have no known link to other outbreaks, the Allen County Department of Health said last week.

Kansas added nine cases Wednesday for a total of 46 across eight counties in the southwest part of the state. Gray County, which had fewer than six cases, is up to 15. The state also reported its first hospitalisation. Kansas’ health department didn’t respond Wednesday to a question about the discrepancy in the number of new cases at the state and county levels. The state’s first reported case is linked to the Texas outbreak based on genetic testing.

Montcalm County, near Grand Rapids in western Michigan, has four linked measles cases. State health officials say the cases are tied to Canada’s large outbreak in Ontario. The state has nine confirmed measles cases as of Friday, but the remaining four are not part of the Montcalm County outbreak.

Nationwide rise tied to travel, low vaccination

Montana state health officials announced five cases April 17 in unvaccinated children and adults who had travelled out of state, and confirmed it was an outbreak April 21. All five are isolating at home in Gallatin County in the southwest part of the state. They are Montana’s first measles cases in 35 years. Health officials didn’t say whether the cases are linked to other outbreaks in North America.

The Ohio Department of Health confirmed 32 measles cases in the state Thursday, and one hospitalisation. The state count includes only Ohio residents. There are 16 cases in Ashtabula County near Cleveland, 14 in Knox County and one each in Allen and Holmes counties.

Health officials in Knox County, in east-central Ohio, said there are a total of 20 people with measles, but seven of them do not live in the state. Oklahoma added two cases Tuesday: 12 confirmed and three probable. The first two probable cases were “associated” with the West Texas and New Mexico outbreaks, the state health department said. The state health department is not releasing which counties have cases, but Cleveland, Custer, Oklahoma and Sequoyah counties have had public exposures in the past couple of months.

There are eight measles cases in Erie County in far northwest Pennsylvania, officials said Friday. The county declared an outbreak in mid-April. The state said Friday it has 13 cases overall in 2025, including international travel-related cases in Montgomery County and one in Philadelphia.

Tennessee has six measles cases as of Thursday. Health department spokesman Bill Christian said all cases are the middle part of the state, and that “at least three of these cases are linked to each other” but declined to specify further. The state also did not say whether the cases were linked to other outbreaks or when Tennessee’s outbreak started.

The state health department announced the state’s first measles case March 21, three more on April 1 and the last two on April 17, but none of the news releases declared an outbreak. Tennessee is on a list of outbreak states in a Thursday CDC report.

There have been 884 cases in 2025 as of Friday, according to the CDC. Measles cases also have been reported in Alaska, Arkansas, California, Colorado, Florida, Georgia, Hawaii, Illinois, Kentucky, Louisiana, Maryland, Minnesota, New Jersey, New York, Rhode Island, Vermont, Virginia and Washington. Cases and outbreaks in the U.S. are frequently traced to someone who caught the disease abroad. In 2019, the U.S. saw 1,274 cases and almost lost its status of having eliminated measles.

Who needs the MMR vaccine and why herd immunity matters

The best way to avoid measles is to get the measles, mumps and rubella vaccine. The first shot is recommended for children between 12 and 15 months old and the second between 4 and 6 years old.

Getting another MMR shot is harmless if there are concerns about waning immunity, the CDC says. People who have documentation of receiving a live measles vaccine in the 1960s don’t need to be revaccinated, but people who were immunized before 1968 with an ineffective measles vaccine made from “killed” virus should be revaccinated with at least one dose, the agency said.

People who have documentation that they had measles are immune and those born before 1957 generally don’t need the shots because most children back then had measles and now have “presumptive immunity.” In communities with high vaccination rates — above 95% — diseases like measles have a harder time spreading through communities. This is called “herd immunity.”

Prevention starts with routine childhood vaccination

But childhood vaccination rates have declined nationwide since the pandemic and more parents are claiming religious or personal conscience waivers to exempt their kids from required shots. The U.S. saw a rise in measles cases in 2024, including an outbreak in Chicago that sickened more than 60.

Measles first infects the respiratory tract, then spreads throughout the body, causing a high fever, runny nose, cough, red, watery eyes and a rash.

The rash generally appears three to five days after the first symptoms, beginning as flat red spots on the face and then spreading downward to the neck, trunk, arms, legs and feet. When the rash appears, the fever may spike over 104 degrees Fahrenheit, according to the CDC.

Most kids will recover from measles, but infection can lead to dangerous complications such as pneumonia, blindness, brain swelling and death. There’s no specific treatment for measles, so doctors generally try to alleviate symptoms, prevent complications and keep patients comfortable.



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China suggests COVID-19 originated in U.S. in response to Trump allegation

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China suggests COVID-19 originated in U.S. in response to Trump allegation


Image for representation.
| Photo Credit: Getty Images/iStockphoto

China restated its case that COVID-19 may have originated in the United States in a white paper on its pandemic response released on Wednesday (April 30, 2025) after President Donald Trump’s administration blamed a lab leak in China.

The White House launched a COVID-19 website on April 18 in which it said the coronavirus came from a lab leak in China while criticising former President Joe Biden, former top U.S. health official Anthony Fauci and the World Health Organization.

Also Read | White House touts COVID-19 ‘lab leak’ theory on revamped site

In the white paper, released by the official Xinhua news agency, China accused the U.S. of politicising the matter of the origins of COVID-19. It cited a Missouri lawsuit which resulted in a $24 billion ruling against China for hoarding protective medical equipment and covering up the outbreak.

China shared relevant information with the WHO and the international community in a timely manner, the white paper said, emphasising that a joint study by the WHO and China had concluded that a lab leak was “extremely unlikely”.

The U.S. should not continue to “pretend to be deaf and dumb”, but should respond to the legitimate concerns of the international community, the white paper said.

“Substantial evidence suggested the COVID-19 might have emerged in the United States earlier than its officially-claimed timeline, and earlier than the outbreak in China,” it said.

Also Read | CIA believes COVID most likely originated from lab but has low confidence in its own finding

The CIA said in January the pandemic was more likely to have emerged from a lab in China than from nature, after the agency had for years said it could not reach a conclusion on the matter. It said it had “low confidence” in its new assessment and noted that both lab origin and natural origin remain plausible.

An official at China’s National Health Commission said the next step in origin-tracing work should focus on the U.S., according to Xinhua, which cited a statement about the white paper.



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Learn about kettlebell lifting, a sport gaining popularity in Tamil Nadu

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Learn about kettlebell lifting, a sport gaining popularity in Tamil Nadu


Rohith G, Vignesh Hariharan and Sharmila Kumari Pinjala at The Hammer kettlebell academy in Kolathur. Photo: Srinivasa Ramanujam. Shot On OnePlus #FramesofIndia

A training session is in the works on the second floor of Kolathur’s The Hammer Fitness gym, on a particularly hot April morning.

Kettlebell coach Vignesh Hariharan is at work, teaching 55-year-old Sharmila Kumari Pinjala the proper method to lift and sustain a weight for a solid period of time. Sharmila, currently a zumba and Pilates instructor based out of Bengaluru, first heard the word ‘kettlebell’ only five years ago when one of her students suggested she introduce it in her dance-cum-fitness sessions.

“I have always been scared of weights. Though I am into fitness, I have never been a gym person. I was sceptical because I didn’t know if I would be able to lift even more than two kilograms,” she laughs, reminiscing about a time before her attempt to take on a certification course in kettlebell lifting.

Today, she is beaming with joy as her first tryst with any sport has resulted in a gold medal part of the OALC (one-arm long cycle) 30-minute category and a bronze in the OALC 10-minute category at the recently-held 12th GSIF Kettlebell National Championship in Goa. Winning a rich tally of medals, the nine-member Tamil Nadu team displayed their prowess at the event that showcased top kettlebell players across the nation.

For Vignesh Hariharan, who has been an integral part of the city’s kettlebell training circuit, this is a moment of reckoning. Vignesh came into popularity in 2019 when he was crowned World Champion in Australia, thus becoming the first person in South India to be awarded the title. “In the Goa event, we had a nine-year-old and a 55-year-old taking part. As a coach, that gave me great joy,” says Vignesh, who also participated in the event, clinching three gold medals in different categories.

‘Never give up’

For the uninitiated, the sport of kettlebell originated in Russia and is still practised by Russian army personnel to hone their physical and mental strength. In Russia, the sport is known as girevoy, and athletes are called gireviks. “It can be played from by a wide group of people, ranging from the age groups of eight to 80. But it will test your patience; that’s when the sport gets intense,” says Vignesh.

Rohith G, a 26-year-old clinical sports physiotherapist, knows a thing or two about this. In his recent outing at Goa, Rohith reached a breaking point when he got a deep cut in his left hand during the first five minutes of the competition. “I was just not able to hold the kettlebell. I was about to give up, but my team pushed me on from the sidelines.”

Rohith was at about 100 repetitions when he was mentally ready to quit but thanks to powerful words of encouragement, he pushed himself to reach 285 repetitions. “It is a cardio workout and helps build endurance. It keeps the heart healthy, but the most important aspect of kettlebell lifting is learning to never give up,” says Rohith, who regularly trains with his pink kettlebell, that weighs eight kilograms and costs around ₹4,500, at home. He then sends video footage to his coach.

His aim? “To win a gold in Asia and World Championship and then train more athletes.” He certainly looks up to his coach Vignesh, who has already produced four World Champions and five National Champions since the time the latter became a World Champion himself. This is despite the fact that a couple of years were lost in adapting to COVID-related lockdowns. He says, “Kettlebell lifting is picking up at a fast rate in the country now, with more awareness about the sport’s benefits to overall fitness and health. From here, up is the only way to go.”



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